Can I read Regulation of GTPase function by autophosphorylation on EtoBox?
Regulation of GTPase function by autophosphorylation by Christian W. Johnson; Hyuk-Soo Seo; Elizabeth M. Terrell; Moon-Hee Yang; Fenneke KleinJan; Teklab Gebregiworgis; Genevieve M.C. Gasmi-Seabrook; Ezekiel A. Geffken; Jimit Lakhani; Kijun Song; Puspalata Bashyal; Olesja Popow; Joao A. Paulo; Andrea Liu; Carla Mattos; Christopher B. Marshall; Mitsuhiko Ikura; Deborah K. Morrison; Sirano Dhe-Paganon; Kevin M. Haigis is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Regulation of GTPase function by autophosphorylation about?
## In brief Johnson et al. identify a group of GTPases that undergo autophosphorylation via a conserved active site substitution. Using RAS A59T as a prototypical autophosphorylating GTPase, they show that autophosphorylation is a stable posttranslational modification that inhibits GTP hydrolysis and enhances nucleotide exchange. Despite promoting cell transformation, autophosphorylation inhibits K-RAS effector interactions.
Who reads Regulation of GTPase function by autophosphorylation?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Christian W. Johnson; Hyuk-Soo Seo; Elizabeth M. Terrell; Moon-Hee Yang; Fenneke KleinJan; Teklab Gebregiworgis; Genevieve M.C. Gasmi-Seabrook; Ezekiel A. Geffken; Jimit Lakhani; Kijun Song; Puspalata Bashyal; Olesja Popow; Joao A. Paulo; Andrea Liu; Carla Mattos; Christopher B. Marshall; Mitsuhiko Ikura; Deborah K. Morrison; Sirano Dhe-Paganon; Kevin M. Haigis
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)