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Role of HMOX1 Promoter Genetic Variants in Chemoresistance and Chemotherapy Induced Neutropenia in Children with Acute Lymphoblastic Leukemia by Karolina Bukowska-Strakova; Joanna Włodek; Ewelina Pitera; Magdalena Kozakowska; Anna Konturek-Cieśla; Maciej Cieśla; Monika Gońka; Witold Nowak; Aleksandra Wieczorek; Katarzyna Pawińska-Wąsikowska; Alicja Józkowicz; Maciej Siedlar is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Role of HMOX1 Promoter Genetic Variants in Chemoresistance and Chemotherapy Induced Neutropenia in Children with Acute Lymphoblastic Leukemia about?
Whilst the survival rates of childhood acute lymphoblastic leukemia (ALL) have increased remarkably over the last decades, the therapy resistance and toxicity are still the major causes of treatment failure. It was shown that overexpression of heme oxygenase-1 (HO-1) promotes proliferation and chemoresistance of cancer cells. In humans, the HO-1 gene (HMOX1) expression is modulated by two polymorphisms in the promoter region: (GT)n-length polymorphism and single-nucleotide polymorphism (SNP) A(−413)T, with short GT repeat sequences and 413-A variants linked to an increased HO-1 inducibility. We found that the short alleles are significantly more frequent in ALL patients in comparison to the control group, and that their presence may be associated with a higher risk of treatment failure, reflecting the role of HO-1 in chemoresistance. We also observed that the presence of short alleles may predispose to develop chemotherapy-induced neutropenia. In case of SNP, the 413-T variant co-segregated with short or long alleles, while 413-A almost selectively co-segregated with long alleles, hence it is not possible to determine if SNPs are actually of phenotypic significance. Our results sug
Who reads Role of HMOX1 Promoter Genetic Variants in Chemoresistance and Chemotherapy Induced Neutropenia in Children with Acute Lymphoblastic Leukemia?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Karolina Bukowska-Strakova; Joanna Włodek; Ewelina Pitera; Magdalena Kozakowska; Anna Konturek-Cieśla; Maciej Cieśla; Monika Gońka; Witold Nowak; Aleksandra Wieczorek; Katarzyna Pawińska-Wąsikowska; Alicja Józkowicz; Maciej Siedlar
- Publisher
- MDPI AG
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)