Can I read Pharmacology of sematilide, a non‐quaternary class III antiarrhythmic agent on EtoBox?

Pharmacology of sematilide, a non‐quaternary class III antiarrhythmic agent by Stanley S. Greenberg; Alan Luisi; John P. Long; Harry E. Williamson is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Pharmacology of sematilide, a non‐quaternary class III antiarrhythmic agent about?

## Abstract Sematilide is a new, non‐quaternary class III antiarrhythmic agent currently undergoing clinical trials. We showed that a quaternary ammonium class III antiarrhythmic agent exhibits few extracardiac effects (Greenberg et al., Drug Dev. Res. 25.107–123, 1992). However, the extracardiac effects of a non‐quaternary, pure class III antiarrhythmic agent are unknown. Sematilide, a pure class III antiarrhythmic agent, is effective in a canine model of arrhythmia at 0.3–1.0 mg/kg, intravenously (i.v.). We compared the nervous system and extracardiac effects of sematilide to acecainide (a class I/III) and several class I antiarrhythmic agents to evaluate the potential side effects of this new drug. Sematilide was devoid of neuropharmacologic activity in the mouse and rat, devoid of gastrointestinal activity in the mouse fed a charcoal meal, and without effect in the rat carrageenan‐induced paw edema test. Ten to 30 times the average antiarrhythmic dose or plasma levels of sematilide were devoid of α~1~, muscarinic, nicotinic, and β‐adrenoceptor blocking activities in a variety of preparations. Moreover, sematilide was devoid of depressant activity on (1) cholinergic, nicotinic,

Who reads Pharmacology of sematilide, a non‐quaternary class III antiarrhythmic agent?

Author

Stanley S. Greenberg; Alan Luisi; John P. Long; Harry E. Williamson

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0272-4391)

Published

1992

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)