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Analysis of Extracranial Stereotactic Radiosurgery via Equivalent Uniform Dose and Tumor Control Probability: Practical Ramifications and Translational Implications by B.D Kavanagh; R.D Timmerman; S.H Benedict; L.E Gaspar; T.E Schefter is a Medicine article available to read on EtoBox.

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Results: Seven days after irradiation, tumour area decrease was equivalent in radioresistant and radiosensitive tumours (37% and 46% respectively, pϭNS) whereas MVD reduction was significantly greater in radiosensitive tumours (mean value: -60%, min: -53%, max -78%) than in radioresistant tumours (mean value: -11%, min: ϩ8%, max: -28%)(pϽ0.05). The late tumour regrowth was correlated with day 7 MVD changes. (p Scheffe test ϭ 0.0036). A 50% MVD reduction value allowed us to discriminate the four radiosensitive tumours at day 25 which had a drastic reduction in MVD from the six others tumours which were radioresistant with a limited MVD reduction (Figure 1). ## Conclusions: Our study suggests that the early assessment of MVD changes after irradiation could predict the long-term tumoural response to irradiation.

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Author

B.D Kavanagh; R.D Timmerman; S.H Benedict; L.E Gaspar; T.E Schefter

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2002

Language

EN

Field

Medicine (Health Sciences)