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Synthesis and antimicrobial properties of cycloheptyl substituted benzimidazolium salts and their silver(I) carbene complexes by Mert Olgun Karataş; Selami Günal; Ahmet Mansur; Bülent Alıcı; Engin Çetinkaya is a Chemistry article available to read on EtoBox.
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## Abstract Due to increasing infections caused by microbes, there is an urgent need for the development of new effective antimicrobial agents. Silver-__N__-heterocyclic carbene (silver-NHC) complexes are a new class of antimicrobial agents. In this study, we aimed to synthesize highly lipophilic silver-NHC complexes. Four new complexes were synthesized by the reaction of the corresponding benzimidazolium salts and Ag~2~O in dichloromethane at room temperature. The synthesized compounds were characterized by ^1^H NMR, ^13^C NMR, IR and elemental analysis. The antimicrobial performances of benzimidazolium salts and silver complexes were tested against the standard bacterial strains __Enterococcus faecalis__, __Staphylococcus aureus__, __Escherichia coli__, __Pseudomonas aeruginosa__ and the fungi __Candida albicans__ and __Candida tropicalis__. Minimum inhibitory concentrations (MICs) of all compounds were determined. The obtained data demonstrate that all benzimidazolium salts and silver complexes inhibit the growth of bacteria and fungi. Silver complexes are more active than the corresponding benzimidazolium salts (MIC: 6.25 μg/mL for Gram-positive bacteria and fungi).
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It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Mert Olgun Karataş; Selami Günal; Ahmet Mansur; Bülent Alıcı; Engin Çetinkaya
- Publisher
- Walter de Gruyter GmbH
- Published
- 2016
- Language
- EN
- Field
- Chemistry (Physical Sciences)
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