About this Medicine article

Homocysteine, MTHFR C677T gene polymorphism, folic acid and vitamin B 12 in patients with retinal vein occlusion by Paola Ferrazzi; Pierpaolo Di Micco; Ilaria Quaglia; Lisa Simona Rossi; Alessandro Giacco Bellatorre; Giorgio Gaspari; Lidia Luciana Rota; Corrado Lodigiani is a Medicine article available to read on EtoBox.

## Background Many available data have suggested that hyperhomocysteinaemia, an established independent risk factor for thrombosis (arterial and venous), may be associated with an increased risk of retinal vein occlusion (RVO). ## Aim of the study To evaluate homocysteine metabolism in consecutive caucasian patients affected by RVO from Northern Italy. ## Patients and Methods 69 consecutive patients from Northern Italy (mean age 64.1 ± 14.6 yy) with recent RVO, were tested for plasma levels of homocysteine (tHcy: fasting and after loading with methionine), cyanocobalamine and folic acid levels (CMIA-Abbot) and looking for MTHFR C677T mutation (Light Cycler-Roche) and compared to 50 volunteers, enrolled as a control group. ## Results Fasting levels of tHcy were significantly higher in patients than in controls: mean value 14.7 ± 7.7 vs 10.2 ± 8 nmol/ml. Post load levels were also significantly higher: mean value 42.7 ± 23.7 vs 30.4 ± 13.3 nmol/ml; Total homocysteine increase was also evaluated (i.e. Δ-tHcy) after methionine load and was also significantly higher in patients compared to control subjects: mean Δ-tHcy 27.8 ± 21.5 vs 21.0 ± 16 nmol/ml (normal value < 25 nmol/ml). Furthe

Author

Paola Ferrazzi; Pierpaolo Di Micco; Ilaria Quaglia; Lisa Simona Rossi; Alessandro Giacco Bellatorre; Giorgio Gaspari; Lidia Luciana Rota; Corrado Lodigiani

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2003-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1477-9560)

Published

2005

Language

EN

Field

Medicine (Health Sciences)