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In Situ Detection of DNA Damage : Methods and Protocols by P. Roy Walker, Christine Carson, Julie Leblanc, Marianna Sikorska (auth.), Vladimir V. Didenko (eds.) is a nonfiction available to read on EtoBox.

What is In Situ Detection of DNA Damage : Methods and Protocols about?

Detection and analysis of DNA damage is critically important in the study of the widest variety of biological phenomena, ranging from apoptosis and aging to heart diseases and anticancer drug development. In In Situ Detection of DNA Damage: Methods and Protocols, Vladimir Didenko and a panel of experts describe all the major in situ techniques for studying DNA damage and apoptosis, and show how approaches originally designed to label apoptotic cells can be used for DNA damage analysis (and vice versa). The readily reproducible techniques presented here include all those designed to detect specific single- and double-stranded DNA breaks in tissue sections while using polymerases, ligases, nucleases, and kinases. In-depth protocols for single-cell electrophoresis (comet assay) are presented, as well as those for the detection of indirect markers of DNA damage and modified bases. Technical reviews discuss specificity, sensitivity, advantages, and limitations of the techniques described, and compare them with alternative approaches. State-of-the-art and highly practical, In Situ Detection of DNA Damage: Methods and Protocols presents for the first time a complete set of enzymatic metho

Who reads In Situ Detection of DNA Damage : Methods and Protocols?

Author

P. Roy Walker, Christine Carson, Julie Leblanc, Marianna Sikorska (auth.), Vladimir V. Didenko (eds.)

Publisher

Humana Press : Imprint : Humana

Published

2002

Language

EN

ISBN

9781592591794

Category

nonfiction

Subjects

Technology, Science, Medical