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Meaningful cognitive decline is uncommon in virally suppressed HIV, but sustained impairment, subtle decline and abnormal cognitive aging are not by Aung, Htein Linn (author);Siefried, Krista J. (author);Gates, Thomas M. (author);Brew, Bruce J. (author);Mao, Limin (author);Carr, Andrew (author);Cysique, Lucette A. (author) is a Medicine article available to read on EtoBox.

What is Meaningful cognitive decline is uncommon in virally suppressed HIV, but sustained impairment, subtle decline and abnormal cognitive aging are not about?

## Summary ## Background High antiretroviral therapy (ART) coverage and viral suppression among people with HIV (PWH) in Australia provide a unique context to study individual cognitive trajectories, cognitive aging and factors associated with longitudinal cognitive function during chronic and stable HIV disease. ## Methods Participants from the Predictors of Adherence to Antiretroviral Therapy study (n = 457, recruited between September 2013 and November 2015, median age = 52 years, and all with HIV RNA 0.5). Meaningful cognitive change was statistically defined (decline or improvement versus stability, i.e., 90% CI, that is p < 0.05, 2-tailed) using a novel evidence-based change score: the linear mixed-effect regression (LMER)-based GZS change score. A separate LMER model with a top-down variable selection approach identified the independent effects of age and other demographic, HIV disease characteristics, socioeconomic and health-related factors on the demographically corrected GZS. The combined definitions of change and cross-sectional impairment enabled the identification of cognitive trajectories. ## Findings At Month-12 and Month-24, 6% and 7% showed meaningful cognitive d

Who reads Meaningful cognitive decline is uncommon in virally suppressed HIV, but sustained impairment, subtle decline and abnormal cognitive aging are not?

Author

Aung, Htein Linn (author);Siefried, Krista J. (author);Gates, Thomas M. (author);Brew, Bruce J. (author);Mao, Limin (author);Carr, Andrew (author);Cysique, Lucette A. (author)

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)