Can I read Triaryl bis-sulfones as a new class of cannabinoid CB2 receptor inhibitors: identification of a lead and initial SAR studies on EtoBox?
Triaryl bis-sulfones as a new class of cannabinoid CB2 receptor inhibitors: identification of a lead and initial SAR studies by Brian J. Lavey; Joseph A. Kozlowski; R. William Hipkin; Waldemar Gonsiorek; Daniel J. Lundell; John J. Piwinski; Satwant Narula; Charles A. Lunn is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Triaryl bis-sulfones as a new class of cannabinoid CB2 receptor inhibitors: identification of a lead and initial SAR studies about?
A novel class of cannabinoid CB2 receptor ligands is described. These triaryl bis-sulfones are nanomolar inhibitors of the CB2 receptor and show high selectivity over the cannabinoid CB1 receptor. One example of this new class decreases ligand-induced GTPcS binding to recombinant CB2 cell membranes, identifying the compound as a CB2-selective inverse agonist.
Who reads Triaryl bis-sulfones as a new class of cannabinoid CB2 receptor inhibitors: identification of a lead and initial SAR studies?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Brian J. Lavey; Joseph A. Kozlowski; R. William Hipkin; Waldemar Gonsiorek; Daniel J. Lundell; John J. Piwinski; Satwant Narula; Charles A. Lunn
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2005
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)