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Ninjurin1 deficiency aggravates colitis development by promoting M1 macrophage polarization and inducing microbial imbalance by Choi, Hoon; Bae, Sung-Jin; Choi, Garam; Lee, Hyunseung; Son, Taekwon; Kim, Jeong-gyun; An, Sunho; Lee, Hye Shin; Seo, Ji Hae; Kwon, Hyouk-Bum; Jeon, Sejin; Oh, Goo Taeg; Surh, Young-Joon; Kim, Kyu-Won is a Medicine article available to read on EtoBox.
What is Ninjurin1 deficiency aggravates colitis development by promoting M1 macrophage polarization and inducing microbial imbalance about?
Disruption of colonic homeostasis caused by aberrant M1/M2 macrophage polarization and dysbiosis contributes to inflammatory bowel disease (IBD) pathogenesis. However, the molecular factors mediating colonic homeostasis are not well characterized. Here, we found that Ninjurin1 (Ninj1) limits colon inflammation by regulating macrophage polarization and microbiota composition under homeostatic conditions and during colitis development. Ninj1 deletion in mice induced hypersusceptibility to colitis, with increased prevalence of colitogenic Prevotellaceae strains and decreased immunoregulatory Lachnospiraceae strains. Upon co-housing (CoH) with WT mice, Ninj1 mice showed increased Lachnospiraceae and decreased Prevotellaceae abundance, with subsequent improvement of colitis. Under homeostatic conditions, M1 macrophage frequency was higher in the Ninj1 mouse colons than wild-type (WT) mouse colons, which may contribute to increased basal colonic inflammation and microbial imbalance. Following colitis induction, Ninj1 expression was increased in macrophages; meanwhile Ninj1 mice showed severe colitis development and impaired recovery, associated with decreased M2 macrophages and escalated
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- Author
- Choi, Hoon; Bae, Sung-Jin; Choi, Garam; Lee, Hyunseung; Son, Taekwon; Kim, Jeong-gyun; An, Sunho; Lee, Hye Shin; Seo, Ji Hae; Kwon, Hyouk-Bum; Jeon, Sejin; Oh, Goo Taeg; Surh, Young-Joon; Kim, Kyu-Won
- Publisher
- The Federation of American Societies for Experimental Biology; Federation of American Society for Experimental Biology; Federation of American Societies for Experimental Biology; Wiley; FASEB (ISSN 0892-6638)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)