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Fetal Cardiovascular Response to Acute Hypoxia During Maternal Anesthesia by Varcoe, Tamara J.; Darby, Jack R. T.; Holman, Stacey L.; Bradshaw, Emma L.; Kuchel, Tim; Vaughan, Lewis; Seed, Michael; Wiese, Michael D.; Morrison, Janna L. is a Medicine article available to read on EtoBox.

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## Abstract Preclinical imaging studies of fetal hemodynamics require anesthesia to immobilize the animal. This may induce cardiovascular depression and confound measures under investigation. We compared the impact of four anesthetic regimes upon maternal and fetal blood gas and hemodynamics during baseline periods of normoxia, and in response to an acute hypoxic challenge in pregnant sheep. Merino ewes were surgically prepared with maternal and fetal vascular catheters and a fetal femoral artery flow probe at 105–109 days gestation. At 110–120 days gestation, ewes were anesthetized with either isoflurane (1.6%), isoflurane (0.8%) plus ketamine (3.6 mg·kg^−1^·h^−1^), ketamine (12.6 mg·kg^−1^·h^−1^) plus midazolam (0.78 mg·kg^−1^·h^−1^), propofol (30 mg·kg^−1^·h^−1^), or remained conscious. Following 60 min of baseline recording, nitrogen was administered directly into the maternal trachea to displace oxygen and induce maternal and thus fetal hypoxemia. During normoxia, maternal PaO~2~ was ~30 mmHg lower in anesthetized ewes compared to conscious controls, regardless of the type of anesthesia (__p__ .05), but heart rate was 32 ± 8 bpm lower in fetuses from ewes administered isoflu

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Author

Varcoe, Tamara J.; Darby, Jack R. T.; Holman, Stacey L.; Bradshaw, Emma L.; Kuchel, Tim; Vaughan, Lewis; Seed, Michael; Wiese, Michael D.; Morrison, Janna L.

Publisher

Wiley (Physiological Reports); John Wiley and Sons Inc.; Wiley; Research Square (ISSN 2051-817X)

Published

2020

Language

EN

Field

Medicine (Health Sciences)