About this Medicine article
Modulation of Host Responses to Blood-stage Malaria by Interleukin-12: from Therapyto Adjuvant Activity by Mary M Stevenson; Zhong Su; Hakeem Sam; Karkada Mohan is a Medicine article available to read on EtoBox.
This review focuses on the role of interleukin (IL)-12, a proinflammatory cytokine with pleiotropic effects as a potent immunoregulatory molecule and hematopoietic growth factor, in infection with Plasmodium parasites, the causative agents of malaria. IL-12 has been demonstrated to have profound effects on the immune response to blood-stage malaria, to induce protection, and to alleviate malarial anemia. In combination with an anti-malarial drug, IL-12 is effective in an established malaria infection. This cytokine also has potent immune effects as a malaria vaccine adjuvant. However, IL-12 can also mediate pathology during blood-stage malaria.
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Mary M Stevenson; Zhong Su; Hakeem Sam; Karkada Mohan
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1286-4579)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Life Sciences)