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Can I read Ceramide Synthase 6 Maximizes p53 Function to Prevent Progeny Formation from Polyploid Giant Cancer Cells on EtoBox?
Ceramide Synthase 6 Maximizes p53 Function to Prevent Progeny Formation from Polyploid Giant Cancer Cells by Lu, Ping (author);White-Gilbertson, Shai (author);Beeson, Gyda (author);Beeson, Craig (author);Ogretmen, Besim (author);Norris, James (author);Voelkel-Johnson, Christina (author) is a Medicine article available to read on EtoBox.
What is Ceramide Synthase 6 Maximizes p53 Function to Prevent Progeny Formation from Polyploid Giant Cancer Cells about?
Polyploid giant cancer cells (PGCC) constitute a transiently senescent subpopulation of cancer cells that arises in response to stress. PGCC are capable of generating progeny via a primitive, cleavage-like cell division that is dependent on the sphingolipid enzyme acid ceramidase (ASAH1). The goal of this study was to understand differences in sphingolipid metabolism between non-polyploid and polyploid cancer cells to gain an understanding of the ASAH1-dependence in the PGCC population. Steady-state and flux analysis of sphingolipids did not support our initial hypothesis that the ASAH1 product sphingosine is rapidly converted into the pro-survival lipid sphingosine-1-phosphate. Instead, our results suggest that ASAH1 activity is important for preventing the accumulation of long chain ceramides such as C16-ceramide. We therefore determined how modulation of C16-ceramide, either through CerS6 or p53, a known PGCC suppressor and enhancer of CerS6-derived C16-ceramide, affected PGCC progeny formation. Co-expression of the CerS6 and p53 abrogated the ability of PGCC to form offspring, suggesting that the two genes form a positive feedback loop. CerS6 enhanced the effect of p53 by signi
Who reads Ceramide Synthase 6 Maximizes p53 Function to Prevent Progeny Formation from Polyploid Giant Cancer Cells?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Lu, Ping (author);White-Gilbertson, Shai (author);Beeson, Gyda (author);Beeson, Craig (author);Ogretmen, Besim (author);Norris, James (author);Voelkel-Johnson, Christina (author)
- Publisher
- MDPI AG
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)