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Determinants of unsuccessful treatment outcomes and mortality among tuberculosis patients in Malaysia: A registry-based cohort study by Tok, Peter Seah Keng; Liew, Su May; Wong, Li Ping; Razali, Asmah; Loganathan, Tharani; Chinna, Karuthan; Ismail, Nurhuda; Kadir, Naim Abdul; EHTESHAM, HASNAIN SEYED is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Introduction The monitoring of tuberculosis (TB) treatment outcomes and examination of the factors affecting these outcomes are important for evaluation and feedback of the national TB control program. This study aims to assess the TB treatment outcomes among patients registered in the national TB surveillance database in Malaysia from 2014 until 2017 and identify factors associated with unsuccessful treatment outcomes and all-cause mortality. ## Materials and methods Using registry-based secondary data, a retrospective cohort study was conducted. TB patients’ sociodemographic characteristics, clinical disease data and treatment outcomes at one-year surveillance were extracted from the database and analyzed. Logistic regression analysis was used to determine factors associated with unsuccessful treatment outcomes and all-cause mortality. ## Results A total of 97,505 TB cases (64.3% males) were included in this study. TB treatment success (cases categorized as cured and completed treatment) was observed in 80.7% of the patients. Among the 19.3% patients with unsuccessful treatment outcomes, 10.2% died, 5.3% were lost to follow-up, 3.6% had outcomes not evaluated while the remaini

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Author

Tok, Peter Seah Keng; Liew, Su May; Wong, Li Ping; Razali, Asmah; Loganathan, Tharani; Chinna, Karuthan; Ismail, Nurhuda; Kadir, Naim Abdul; EHTESHAM, HASNAIN SEYED

Publisher

Public Library of Science; San Francisco CA: Public Library of Science; Publons; ScienceOpen; Public Library of Science (PLoS) (ISSN 1932-6203)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)