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In vitro and in vivo effectiveness of arsenic trioxide against murine T-cell prolymphocytic leukaemia by Christian Récher; Martine Chopin; Emmanuel Raffoux; Gaëlle Pierron; Joël Poupon; François Sigaux; Hervé Dombret; Marc-Henri Stern is a Medicine article available to read on EtoBox.

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**Summary.** T‐cell prolymphocytic leukaemia (T‐PLL) is a rare form of mature T‐cell leukaemia that is generally resistant to conventional chemotherapy. Mice transgenic for __MTCP1__ develop leukaemia similar to human T‐PLL, providing a model useful for testing therapeutics. We here evaluated the potential effectiveness of arsenic trioxide (ATO) in murine T‐PLL. __In vitro__, ATO consistently reduced the viability of murine T‐PLL cells at a clinically achievable concentration (1 μmol/l). The percentage of viable cells after 24 h was 77 ± 4%, 56 ± 6%, 31 ± 7% with 0 μmol/l, 0·5 μmol/l and 1 μmol/l ATO respectively. ATO cytotoxicity was enhanced by ascorbic acid (125 μmol/l). Mice were then treated with ATO (5 μg/g/d intra peritoneally, 5 d per week) or saline for 4 weeks, starting 14 d after tumoral engraftment. The appearance of lymphocytosis and splenomegaly was delayed in the group treated with ATO and survival was significantly prolonged (mean survival in days: 57·6 ± 0·8 for ATO versus 45 ± 0 for saline, __P__ < 10^−4^). No additional effect was observed __in vivo__ by combining ATO with ascorbic acid (500 μg/g/d, 5 d per week, intra peritoneally). These findings provide suppor

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Author

Christian Récher; Martine Chopin; Emmanuel Raffoux; Gaëlle Pierron; Joël Poupon; François Sigaux; Hervé Dombret; Marc-Henri Stern

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)

Published

2002

Language

EN

Field

Medicine (Health Sciences)