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Efficacy and tolerability of combination treatment of topiramate and greater occipital nerve block versus topiramate monotherapy for the preventive treatment of chronic migraine: A randomized controlled trial by Debashish Chowdhury; Ankit Mundra; Debabrata Datta; Ashish Duggal; Anand Krishnan; Arun Koul is a Medicine article available to read on EtoBox.
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## Objective To compare the efficacy and tolerability of combination treatment of topiramate and greater occipital nerve block to topiramate monotherapy in adult chronic migraine patients. ## Background Options for the preventive treatment of chronic migraine are limited and costly. Combination treatments do not have an evidence base yet. ## Methods This was a parallel group, 3 arms with 1:1:1 allocation ratio randomized controlled study in consecutive adult chronic migraine patients attending Headache Clinic in a tertiary care hospital. Patients received either topiramate monotherapy 100 mg/day (group A), or topiramate plus greater occipital nerve block with 40 mg lidocaine (2%) and 80mg (2 ml) methylprednisolone as the first injection followed by monthly injections of lidocaine for the next 2 months (group B) or topiramate plus greater occipital nerve block with 40 mg lidocaine (2%) injections monthly for 3 months (group C). The primary endpoint was the mean change in monthly migraine days at Month 3. Multiple secondary endpoints were assessed that included among others, achievement of ≥50% reduction in mean monthly headache days compared to baseline at Month 3 and assessment for
Who reads Efficacy and tolerability of combination treatment of topiramate and greater occipital nerve block versus topiramate monotherapy for the preventive treatment of chronic migraine: A randomized controlled trial?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Debashish Chowdhury; Ankit Mundra; Debabrata Datta; Ashish Duggal; Anand Krishnan; Arun Koul
- Publisher
- SAGE Publications
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)