Can I read Modified Gellan Gum-based Hydrogel with Enhanced Mechanical Properties for Application as a Cell Carrier for Cornea Endothelial Cells on EtoBox?

Modified Gellan Gum-based Hydrogel with Enhanced Mechanical Properties for Application as a Cell Carrier for Cornea Endothelial Cells by Jin Sol Seo; Nomin-Erdene Tumursukh; Joo Hee Choi; Youngeun Song; Gayeong Jeon; Na Eun Kim; Seung Jae Kim; Nahyeon Kim; Jeong Eun Song; Gilson Khang is a Materials Science article available to read on EtoBox.

What is Modified Gellan Gum-based Hydrogel with Enhanced Mechanical Properties for Application as a Cell Carrier for Cornea Endothelial Cells about?

Recently, the number of people suffering from visual loss due to eye diseases is increasing rapidly around the world. However, due to the severe donor shortage and the immune response, corneal replacement is needed. Gellan gum (GG) is biocompatible and widely used for cell delivery or drug delivery, but its strength is not suitable for the corneal substitute. In this study, a GM hydrogel was prepared by blending methacrylated gellan gum with GG (GM) to give suitable mechanical properties to the corneal tissue. In addition, lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP), a crosslinking initiator, was added to the GM hydrogel. After the photo-crosslinking treatment, it was named GM/LAP hydrogel. GM and GM/LAP hydrogels were analyzed for physicochemical properties, mechanical characterization, and transparency tests to confirm their applicability as carriers for corneal endothelial cells (CEnCs). Also, in vitro studies were performed with cell viability tests, cell proliferation tests, cell morphology, cell-matrix remodeling analysis, and gene expression evaluation. The compressive strength of the GM/LAP hydrogel was improved compared to the GM hydrogel. The GM/LAP hydrogel sh

Who reads Modified Gellan Gum-based Hydrogel with Enhanced Mechanical Properties for Application as a Cell Carrier for Cornea Endothelial Cells?

Author

Jin Sol Seo; Nomin-Erdene Tumursukh; Joo Hee Choi; Youngeun Song; Gayeong Jeon; Na Eun Kim; Seung Jae Kim; Nahyeon Kim; Jeong Eun Song; Gilson Khang

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Materials Science (Physical Sciences)