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Folate Pathway Polymorphisms Predict Deficits in Attention and Processing Speed After Childhood Leukemia Therapy by Kala Y. Kamdar; Kevin R. Krull; Randa A. El‐Zein; Pim Brouwers; Brian S. Potter; Lynnette L. Harris; Suzanne Holm; ZoAnn Dreyer; Fernando Scaglia; Carol J. Etzel; Melissa Bondy; M. Fatih Okcu is a Medicine article available to read on EtoBox.
What is Folate Pathway Polymorphisms Predict Deficits in Attention and Processing Speed After Childhood Leukemia Therapy about?
## Abstract ## Background Neurocognitive impairment occurs in 20–40% of childhood acute lymphoblastic leukemia (ALL) survivors, possibly mediated by folate depletion and homocysteine elevation following methotrexate treatment. We evaluated the relationship between folate pathway polymorphisms and neurocognitive impairment after childhood ALL chemotherapy. ## Procedure Seventy‐two childhood ALL survivors treated with chemotherapy alone underwent a neurocognitive battery consisting of: Trail Making Tests A (TMTA) and B (TMTB), Grooved Pegboard Test Dominant‐Hand and Nondominant‐Hand, Digit Span subtest, and Verbal Fluency Test. We performed genotyping for: 10‐methylenetetrahydrofolate reductase (__MTHFR__ 677C>T and __MTHFR__ 1298A>C), serine hydroxymethyltransferase (__SHMT__ 1420C>T), methionine synthase (__MS__ 2756 A>G), methionine synthase reductase (__MTRR__ 66A>G), and thymidylate synthase (__TSER__). Student's two sample __t__‐test and analysis of covariance were used to compare test scores by genotype. ## Results General impairment on the neurocognitive battery was related to __MTHFR__ 1298A>C (__P__ = 0.03) and __MS__ 2756A>G (__P__ = 0.05). Specifically, survivors with __M
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- Author
- Kala Y. Kamdar; Kevin R. Krull; Randa A. El‐Zein; Pim Brouwers; Brian S. Potter; Lynnette L. Harris; Suzanne Holm; ZoAnn Dreyer; Fernando Scaglia; Carol J. Etzel; Melissa Bondy; M. Fatih Okcu
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)