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In Vivo Effects of Low Level Laser Therapy on Inducible Nitric Oxide Synthase by Yumi Moriyama; Jacqueline Nguyen; Margarete Akens; Eduardo H. Moriyama; Lothar Lilge is a Medicine article available to read on EtoBox.

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## Abstract ## Background and Objective Low level laser therapy (LLLT) has been demonstrated to modulate inflammatory processes with evidence suggesting that treatment protocol, such as wavelength, total energy, and number of treatments determine the clinical efficacy. In this study, the effects of LLLT mediated by different wavelengths and continuous versus pulsed delivery mode were quantified in a transgenic murine model with the luciferase gene under control of the inducible nitric oxide synthase (iNOS) expression. ## Study Design/Materials and Methods LLLT modulated iNOS gene expressed in the acute Zymosan‐induced inflammation model is quantified using transgenic mice (FVB/N‐Tg(iNOS‐luc)). Here an energy density of 5 J cm^−2^ at either 635, 660, 690, and 905 nm in continuous wave mode and at 905 nm for short pulse delivery were evaluated. Age of the animals was determined as additional modulating the inflammatory response and the LLLT efficacy for some treatment protocols. ## Results Animals younger than 15 weeks showed mostly reduction of iNOS expression, while older animals showed increased iNOS expression for some LLLT protocols. Intensity and time course of inducible nitric

Who reads In Vivo Effects of Low Level Laser Therapy on Inducible Nitric Oxide Synthase?

Author

Yumi Moriyama; Jacqueline Nguyen; Margarete Akens; Eduardo H. Moriyama; Lothar Lilge

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0196-8092)

Published

2009

Language

EN

Field

Medicine (Health Sciences)