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Matrix Metalloproteinase-9gene Polymorphisms in Nasal Polyposis by Ling-Feng Wang; Chen-Yu Chien; Chih-Feng Tai; Wen-Rei Kuo; Edward Hsi; Suh-Hang Hank Juo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract ## Background Matrix metalloproteinase (MMP) is involved in the upper airway remodeling process. We hypothesized that genetic variants of the __MMP-9__ gene are associated with cases of chronic rhinosinusitis with nasal polyposis. ## Methods We conducted a case-control study where 203 cases of chronic rhinosinusitis with nasal polyposis and 730 controls were enrolled. Three tagging single nucleotide polymorphisms (SNPs) and one promoter functional SNP rs3918242 were selected. Hardy-Weinberg equilibrium (HWE) was tested for each SNP, and genetic effects were evaluated according to three inheritance modes. Haplotype analysis was also performed. Permutation was used to adjust for multiple testing. ## Results All four SNPs were in HWE. The T allele of promoter SNP rs3918242 was associated with chronic rhinosinusitis with nasal polyposis under the dominant (nominal p = 0.023, empirical p = 0.022, OR = 1.62) and additive models (nominal p= 0.012, empirical p = 0.011, OR = 1.60). The A allele of rs2274756 has a nominal p value of 0.034 under the dominant model and 0.020 under the additive model. Haplotype analysis including the four SNPs showed a global p value of 0.015 and th

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Author

Ling-Feng Wang; Chen-Yu Chien; Chih-Feng Tai; Wen-Rei Kuo; Edward Hsi; Suh-Hang Hank Juo

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC (ISSN 1471-2350)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)