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Alteration in cyclic adenosine 3′:5′-monophosphate binding proteins during the phenotypic change of mouse macrophages transformed by a temperature-sensitive mutant (tsA640) of SV40 by Hisao Takayama; Takahiko Tanigawa; Yoshinori Tanaka; Kazukiyo Onodera is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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ku Tokyo 113, (K. O.), Japan By using a photoaffinity ligand, cell extracts from transformed macrophages that were established by infection with temperature-sensitive mutants (tsA640) of simian virus 40 (SV40) were examined for cyclic adenosine 3'5'-monophosphate (CAMP)-binding proteins. At the nonpermissive temperature for SV40 large T antigen, 39.OoC, no significant CAMP-binding proteins could be detected, such as primary mouse macrophages. At t h e permissive temperature of 33.OoC, CAMP-binding proteins appeared later than SV40 T antigen expression and cellular DNA synthesis. The profile of CAMP-binding proteins was similar to that of resting, but not proliferating, mouse clonal fibroblasts (BALBI c 3T3). These and previous results suggest that SV40 T antigen influences the expression of CAMP-binding proteins in tsA640-transformed macrophages; the large/small T antigen converts the profile of CAMP-binding proteins from macrophage to fibroblastic cells.

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Author

Hisao Takayama; Takahiko Tanigawa; Yoshinori Tanaka; Kazukiyo Onodera

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

1986

Language

EN

ISBN

9781041270119

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)