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Metabolic Profiling of Mice Plasma, Bile, Urine and Feces After Oral Administration of Two Licorice Flavonones by Zhang, Lin; Wang, Chen-xiang; Wu, Jing; Wang, Tian-Yun; Zhong, Qiao-qiao; Du, Yan; Ji, Shuai; Wang, Liang; Guo, Meng-Zhe; Xu, Sheng-qiu; Tang, Dao-Quan is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Metabolic Profiling of Mice Plasma, Bile, Urine and Feces After Oral Administration of Two Licorice Flavonones about?
## Ethnopharmacological relevance: Licorice is an ancient food and medicinal plant. liquiritigenin and liquiritin, two kinds of major flavonoes in licorice, are effective substances used as antioxidant, anti-inflammatory and tumor-suppressive food, cosmetics or medicines. however, their in vivo metabolites have not been fully explored. ## Aim of study: To clarify the metabolism of liquiritigenin and liquiritin in mice. ## Materials and methods: In this study, we developed a liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry approach to determine the metabolites in mice plasma, bile, urine and feces after oral administration of liquiritigenin or liquiritin. the structures of those metabolites were tentatively identified according to their fragment pathways, accurate masses, characteristic product ions, metabolism laws or reference standard matching. ## Results: A total of 26 and 24 metabolites of liquiritigenin or liquiritin were respectively identified. the products related with apigenin, luteolin or quercetin were the major metabolites of liquiritigenin or liquiritin in mice. seven main metabolic pathways including (de)hydrogenation, (de)hydroxylation,
Who reads Metabolic Profiling of Mice Plasma, Bile, Urine and Feces After Oral Administration of Two Licorice Flavonones?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Zhang, Lin; Wang, Chen-xiang; Wu, Jing; Wang, Tian-Yun; Zhong, Qiao-qiao; Du, Yan; Ji, Shuai; Wang, Liang; Guo, Meng-Zhe; Xu, Sheng-qiu; Tang, Dao-Quan
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-8741)
- Published
- 2020
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)