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Intragenic hypomethylation of DNMT3A in patients with myelodysplastic syndrome by Ying-Ying Zhang; Jing-Dong Zhou; Dong-Qin Yang; Pin-Fang He; Dong-Ming Yao; Zhen Qian; Jing Yang; Wen-Rong Xu; Jiang Lin; Jun Qian is a Medicine article available to read on EtoBox.

What is Intragenic hypomethylation of DNMT3A in patients with myelodysplastic syndrome about?

## Abstract ## Background: __DNMT3A__ is a DNA methyltransferase that acts in __de novo__ methylation. Aberrant expression of __DNMT3A__ has been reported in several human diseases, including myelodysplastic syndrome (MDS). However, the pattern of __DNMT3A__ methylation remains unknown in MDS. ## Methods: The present study was aimed to investigate the methylation status of __DNMT3A__ intragenic differentially methylated region 2 (DMR2) using real-time quantitative methylation-specific PCR and analyze its clinical significance in MDS. ## Results: Aberrant hypomethylation of __DNMT3A__ was found in 57% (51/90) MDS cases. There were no significant differences in age, sex, white blood cell counts, platelet counts, hemoglobin counts and World Health Organization, International Prognostic Scoring System and karyotype classifications between __DNMT3A__ hypomethylated and __DNMT3A__ hypermethylated groups. However, the patients with __DNMT3A__ hypomethylation had shorter overall survival time than those without __DNMT3A__ hypomethylation (11 months vs. 36 months, p=0.033). Multivariate analysis confirmed the independent adverse impact of __DNMT3A__ hypomethylation in MDS. ## Conclusions: O

Who reads Intragenic hypomethylation of DNMT3A in patients with myelodysplastic syndrome?

Author

Ying-Ying Zhang; Jing-Dong Zhou; Dong-Qin Yang; Pin-Fang He; Dong-Ming Yao; Zhen Qian; Jing Yang; Wen-Rong Xu; Jiang Lin; Jun Qian

Publisher

Walter de Gruyter GmbH

Published

2017

Language

EN

Field

Medicine (Health Sciences)