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Can I read Calmodulin-like Effect of Oncomodulin on Cell Proliferation on EtoBox?
Calmodulin-like Effect of Oncomodulin on Cell Proliferation by Janaki K. Blum; Martin W. Berchtold is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Calmodulin-like Effect of Oncomodulin on Cell Proliferation about?
Oncomodulin (OM) is a Ca2+ binding protein (CABP) structurally closely related to parvalbumin. Expression of OM is restricted to early embryonic stages, the placental cytotrophoblasts, and neoplastic tissues. The function of OM as a calmodulin (CaM)-like enzyme modulator is controversial. Two types of experiments demonstrate that O M may act in an analogous fashion to CaM in T14 and T10 cancerous cell tines, which both express OM. First, both OM transcript and protein levels increased at the Gl/S boundary in a similar manner to CaM, though not to the same extent, in the chemically transformed rat fibroblast cell line T14 synchronized at mitosis by nocodazole. Second, antisense oligonucleotides specific to the OM ATG region inhibited growth of T14 in a similar dose-dependent manner as observed with CaM-specific antisense probes.
Who reads Calmodulin-like Effect of Oncomodulin on Cell Proliferation?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Janaki K. Blum; Martin W. Berchtold
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)
- Published
- 1994
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)