Can I read On the structural repertoire of pools of short, random RNA sequences on EtoBox?

On the structural repertoire of pools of short, random RNA sequences by Michael Stich; Carlos Briones; Susanna C. Manrubia is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is On the structural repertoire of pools of short, random RNA sequences about?

A detailed knowledge of the mapping between sequence and structure spaces in populations of RNA molecules is essential to better understand their present-day functional properties, to envisage a plausible early evolution of RNA in a prebiotic chemical environment and to improve the design of in vitro evolution experiments, among others. Analysis of natural RNAs, as well as in vitro and computational studies, show that certain RNA structural motifs are much more abundant than others, pointing out a complex relation between sequence and structure. Within this framework, we have investigated computationally the structural properties of a large pool (10 8 molecules) of single-stranded, 35 nt-long, random RNA sequences. The secondary structures obtained are ranked and classified into structure families. The number of structures in main families is analytically calculated and compared with the numerical results. This permits a quantification of the fraction of structure space covered by a large pool of sequences. We further show that the number of structural motifs and their frequency is highly unbalanced with respect to the nucleotide composition: simple structures such as stemloops and

Who reads On the structural repertoire of pools of short, random RNA sequences?

Author

Michael Stich; Carlos Briones; Susanna C. Manrubia

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-5193)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)