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Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis by Laure Elkrief; Nathalie Ganne-Carrié; Hana Manceau; Marion Tanguy; Shantha Ram Valainathan; Alix Riescher-Tuczkiewicz; Louise Biquard; Nathalie Barget; Cendrine Chaffaut; Alexandre Louvet; Valérie Paradis; Marianne Ziol; Rikke Bæk; Malene Møller Jørgensen; Guillaume Van Niel; Pierre-Michael Coly; Adel Hammoutène; Fanny Dujardin; Katell Peoc’h; Thierry Poynard; Sylvie Chevret; Pierre-Emmanuel Rautou is a Medicine article available to read on EtoBox.
What is Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis about?
In patients with compensated alcohol-related cirrhosis, reliable prognostic biomarkers are lacking. Keratin-18 and hepatocyte-derived large extracellular vesicles (lEVs) concentrations reflect disease activity, but their ability to predict liver-related events is unknown. Methods We measured plasma keratin-18 and hepatocyte lEVs concentrations in 500 patients with Child-Pugh class A alcohol-related cirrhosis. Ability of these hepatocyte-derived biomarkers, alone or combined with MELD and FibroTest, to predict liver-related events at 2 years was analyzed, taking into account the alcohol consumption at inclusion and during the follow-up. Results Keratin-18 and hepatocyte lEVs concentrations increased with alcohol consumption. In patients without active alcohol consumption at enrollment (n=419), keratin-18 concentration predicted liver-related events at 2 years, independently of FibroTest and MELD. Patients with both keratin-18 concentration >285 U/L and FibroTest >0.74 had a 24% cumulative incidence of liver-related events at 2 years, versus 5% to 14% in other groups of patients. Similar results were obtained when combining keratin-18 concentration >285 U/L with MELD >10. In patients
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- Author
- Laure Elkrief; Nathalie Ganne-Carrié; Hana Manceau; Marion Tanguy; Shantha Ram Valainathan; Alix Riescher-Tuczkiewicz; Louise Biquard; Nathalie Barget; Cendrine Chaffaut; Alexandre Louvet; Valérie Paradis; Marianne Ziol; Rikke Bæk; Malene Møller Jørgensen; Guillaume Van Niel; Pierre-Michael Coly; Adel Hammoutène; Fanny Dujardin; Katell Peoc’h; Thierry Poynard; Sylvie Chevret; Pierre-Emmanuel Rautou
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)