About this document
SHDT 2 by dthuyynguyen is a document available to read on EtoBox.
Lynch syndrome is primarily caused by defects in DNA mismatch repair (MMR) proteins, leading to genomic instability and increased cancer risk. The syndrome is inherited in an autosomal dominant pattern, with germline mutations in MMR genes resulting in microsatellite instability (MSI) and tumor development. Additionally, epigenetic mechanisms such as MLH1 promoter hypermethylation can also contribute to MMR protein loss, further impacting cancer progression and treatment responses.
- Author
- dthuyynguyen
- Language
- EN