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This document describes a study that developed mucoadhesive in situ gelling formulations using chitosan and β-glycerophosphate for intravesical delivery of mitomycin-C to treat bladder cancer. Three different molecular weights of chitosan were used to prepare the formulations. The ability of the formulations to form gels upon temperature change, their mucoadhesive properties, drug release, and retention in ex vivo porcine bladder tissue were evaluated. Formulations prepared from the highest molecular weight

Author

Vishwajeet Ghorpade

Language

EN