About this Biochemistry, Genetics and Molecular Biology article

Evolutionary Conservation in Multiple Faces of Protein Interaction by Yoon Sup Choi; Jae-Seong Yang; Yonghwan Choi; Sung Ho Ryu; Sanguk Kim is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

## Abstract Protein interfaces are believed to be evolutionarily more conserved than the rest of the protein surface, but this has not been properly verified using a large protein structural set. Furthermore, recent systematic protein interaction analyses have proved that proteins interacting with many partners have multiple interfaces to connect protein interaction networks, which have never taken into account for conservation analysis of protein interface. Here, we studied the evolutionary conservation of protein interfaces using a large‐scale dataset of 2646 protein interfaces with the classification of homodimeric/heterodimeric and obligatory/transient interactions, considering all their known multiple interfaces. We found that protein interfaces were indeed more conserved than noninterface surfaces, and the conservation level of protein interfaces increased when multiple interfaces were properly considered. These findings suggest that conservation analysis should be a good descriptor for protein interface identification and protein–protein interaction predictions. We applied this evolutionary feature to filter docking decoys and found that protein interface conservation worked

Author

Yoon Sup Choi; Jae-Seong Yang; Yonghwan Choi; Sung Ho Ryu; Sanguk Kim

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0887-3585)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)