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Can I read AOP-helpFinder 2.0: Integration of an event-event searches module on EtoBox?
AOP-helpFinder 2.0: Integration of an event-event searches module by Thomas Jaylet; Thibaut Coustillet; Florence Jornod; Patricia Margaritte-Jeannin; Karine Audouze is a Environmental Science article available to read on EtoBox.
What is AOP-helpFinder 2.0: Integration of an event-event searches module about?
To support the use of alternative methods in regulatory assessment of chemical risks, the concept of adverse outcome pathway (AOP) constitutes an important toxicological tool. AOP represents a structured representation of existing knowledge, linking molecular initiating event (MIE) initiated by a prototypical stressor that leads to a cascade of biological key event (KE) to an adverse outcome (AO). Biological information to develop such AOP is very dispersed in various data sources. To increase the chance of capturing relevant existing data to develop a new AOP, the AOP-helpFinder tool was recently implemented to assist researchers to design new AOP. Here, an updated version of AOP-helpFinder proposes novel functionalities. The main one being the implementation of an automatic screening of the abstracts from the PubMed database to identify and extract event-event associations. In addition, a new scoring system was created to classify the identified co-occurred terms (stressor-event or event-event (which represent key event relationships) to help prioritization and support the weight of evidence approach, allowing a global assessment of the strength and reliability of the AOP. Moreov
Who reads AOP-helpFinder 2.0: Integration of an event-event searches module?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Thomas Jaylet; Thibaut Coustillet; Florence Jornod; Patricia Margaritte-Jeannin; Karine Audouze
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Environmental Science (Physical Sciences)