Opening book details…
Can I read The Toxicity and Therapeutic Effects of Single-and Multi-wall Carbon Nanotubes on Mice Breast Cancer on EtoBox?
The Toxicity and Therapeutic Effects of Single-and Multi-wall Carbon Nanotubes on Mice Breast Cancer by Kavosi, Arghavan; Hosseini Ghale Noei, Saeideh; Madani, Samaneh; Khalighfard, Solmaz; Khodayari, Saeed; Khodayari, Hamid; Mirzaei, Malihe; Kalhori, Mohammad Reza; Yavarian, Majid; Alizadeh, Ali Mohammad; Falahati, Mojtaba is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The Toxicity and Therapeutic Effects of Single-and Multi-wall Carbon Nanotubes on Mice Breast Cancer about?
## Abstract Herein, we have investigated the toxicity of SWCNTs and MWCNTs __in vitro__ and __in vivo__, and assessed their therapeutic effects on a typical animal model of breast cancer in order to obtain: first, the cytotoxicity effects of CNTs on MC4L2 cell and mice, second the impact of CNTs on ablation of breast tumor. CNTs especially SWCNTs were toxic to organs and induced death at high dosages. In this case, some of the liver cells showed a relative shrinkage which was also confirmed by Annexin test in MC4L2 cells. Moreover, CNTs decreased the tumor volume. BCL2 gene was down-regulated, and BAX and Caspase-3 were also up-regulated in the treated groups with CNTs. As a result, CNTs especially MWCNT in lower dosages can be used as a promising drug delivery vehicle for targeted therapy of abnormal cells in breast cancer.
Who reads The Toxicity and Therapeutic Effects of Single-and Multi-wall Carbon Nanotubes on Mice Breast Cancer?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Kavosi, Arghavan; Hosseini Ghale Noei, Saeideh; Madani, Samaneh; Khalighfard, Solmaz; Khodayari, Saeed; Khodayari, Hamid; Mirzaei, Malihe; Kalhori, Mohammad Reza; Yavarian, Majid; Alizadeh, Ali Mohammad; Falahati, Mojtaba
- Publisher
- Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)
- Published
- 2018
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)