Can I read Diagnosing and Treating Neurogenic Orthostatic Hypotension in Primary Care on EtoBox?

Diagnosing and Treating Neurogenic Orthostatic Hypotension in Primary Care by Louis Kuritzky; Alberto J. Espay; Jeffrey Gelblum; Richard Payne; Eric Dietrich is a Medicine article available to read on EtoBox.

What is Diagnosing and Treating Neurogenic Orthostatic Hypotension in Primary Care about?

In response to a change in posture from supine or sitting to standing, autonomic reflexes normally maintain blood pressure (BP) by selective increases in arteriovenous resistance and by increased cardiac output, ensuring continued perfusion of the central nervous system. In neurogenic orthostatic hypotension (NOH), inadequate vasoconstriction and cardiac output cause BP to drop excessively, resulting in inadequate perfusion, with predictable symptoms such as dizziness, lightheadedness and falls. The condition may represent a central failure of baroreceptor signals to modulate cardiovascular function, a peripheral failure of norepinephrine release from cardiovascular sympathetic nerve endings, or both. Symptomatic patients may benefit from both non-pharmacologic and pharmacologic interventions. Among the latter, two pressor agents have been approved by the US Food and Drug Administration: the sympathomimetic prodrug midodrine, approved in 1996 for symptomatic orthostatic hypotension, and the norepinephrine prodrug droxidopa, approved in 2014, which is indicated for the treatment of symptomatic neurogenic orthostatic hypotension caused by primary autonomic failure (Parkinson's diseas

Who reads Diagnosing and Treating Neurogenic Orthostatic Hypotension in Primary Care?

Author

Louis Kuritzky; Alberto J. Espay; Jeffrey Gelblum; Richard Payne; Eric Dietrich

Publisher

Informa UK Limited

Published

2015

Language

EN

Field

Medicine (Health Sciences)