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Opportunistic infection at the start of antiretroviral therapy and baseline CD4+ count less than 50 cells/mm3 are associated with poor immunological recovery by Amod Tilak; Smita Shenoy; Muralidhar Varma; Asha Kamath; Amruta Tripathy; Ravi Sori; Kavitha Saravu is a Medicine article available to read on EtoBox.
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## Abstract ## Introduction There is a dearth of studies assessing the efficacy and immunological improvement in patients started on antiretroviral therapy (ART) in India. This study was undertaken to assess the 2-year treatment outcomes in HIV-positive patients initiated on ART in a tertiary-care hospital. ## Methods After approval from the Institutional Ethics Committee, adult HIV-positive patients from a tertiary-care hospital, initiated on ART between January 2013 and February 2015, were included in the study. Data on clinical and immunological parameters were obtained from medical case records over a period of 2 years after initiation of therapy. Intention-to-treat analysis was done using a descriptive approach, using SPSS version 15 (SPSS Inc. Released 2006. SPSS for Windows, Version 15.0. Chicago, SPSS Inc.). A logistic regression analysis was done to assess the predictors for poor outcomes. A p-value <0.05 was considered statistically significant. ## Results ART was initiated in 299 adult patients. At 1 and 2 years, the median (interquartile range) change in CD4^+^cell count was 65 (39, 98) cells/mm^3^and 160 (95, 245) cells/mm^3^. The change observed after 2 years of treat
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- Author
- Amod Tilak; Smita Shenoy; Muralidhar Varma; Asha Kamath; Amruta Tripathy; Ravi Sori; Kavitha Saravu
- Publisher
- Walter de Gruyter GmbH
- Published
- 2019
- Language
- EN
- Field
- Medicine (Life Sciences)