Can I read Targeting the DNA Damage Response for Anti-Cancer Therapy on EtoBox?

Targeting the DNA Damage Response for Anti-Cancer Therapy by Pollard, John; Curtin, Nicola is a scholarly article available to read on EtoBox.

What is Targeting the DNA Damage Response for Anti-Cancer Therapy about?

Over the past decade a complex role for DNA damage response (DDR) in tumorigenesis has emerged. A proficient DDR has been shown to be a primary cause for cellular resistance to the very many DNA damaging drugs, and IR, that are widely used as standard-of-care across multiple cancer types. It has also been shown that defects in this network, predominantly within the ATM mediated signaling pathway, are commonly observed in cancers and may be a primary event during tumorigenesis. Such defects may promote a genomically unstable environment, facilitating the persistence of mutations, any of which may provide a growth or survival advantage to the developing tumor. In addition, these somatic defects provide opportunities to exploit a reliance on remaining repair pathways for survival, a process which has been termed synthetic lethality. As a result of all these observations there has been a great interest in targeting the DDR to provide anti-cancer agents that may have benefit as monotherapy in cancers with high background DNA damage levels or as a means to increase the efficacy of DNA damaging drugs and IR. In this book we will review a series of important topics that are of great intere

Author

Pollard, John; Curtin, Nicola

Publisher

Springer International Publishing : Imprint : Humana Press

Published

2018

Language

EN

ISBN

9783319758343