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This study investigates the role of constitutive soxR mutations in contributing to multiple-antibiotic resistance in clinical Escherichia coli isolates. The researchers found that three out of six strains exhibited constitutive soxS expression due to point mutations in the soxR gene, while the mechanism for increased soxS expression in the remaining strains was unclear. The findings highlight the significance of the soxRS regulon in antibiotic resistance and the genetic diversity present in clinical E. coli

Author

luis.orjuela

Language

EN