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Differential effects of teriparatide on regional bone formation using ^18^F‐fluoride positron emission tomography by Michelle L Frost; Musib Siddique; Glen M Blake; Amelia EB Moore; Paul J Schleyer; Joel T Dunn; Edward J Somer; Paul K Marsden; Richard Eastell; Ignac Fogelman is a Medicine article available to read on EtoBox.

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## Abstract Teriparatide increases skeletal mass, bone turnover markers, and bone strength, but local effects on bone tissue may vary between skeletal sites. We used positron emission tomography (PET) to study ^18^F‐fluoride plasma clearance (__K__~__i__~) at the spine and standardized uptake values (SUVs) at the spine, pelvis, total hip, and femoral shaft in 18 postmenopausal women with osteoporosis. Subjects underwent a 1‐hour dynamic scan of the lumbar spine and a 10‐minute static scan of the pelvis and femurs at baseline and after 6 months of treatment with 20 μg/day teriparatide. Blood samples were taken to derive the arterial input function and lumbar spine __K__~__i__~ values evaluated using a three‐compartment model. SUVs were calculated for the spine, pelvis, total hip, and femoral shaft. After 6 months treatment with teriparatide, spine __K__~__i__~ values increased by 24% (__p__= .0003), while other model parameters were unchanged except for the fraction of tracer going to bone mineral (__k__~__3__~/[__k__~__2__~ + __k__~__3__~]), which increased by 23% (__p__= .0006). In contrast to __K__~__i__~, spine SUVs increased by only 3% (__p__= .84). The discrepancy between chan

Who reads Differential effects of teriparatide on regional bone formation using ^18^F‐fluoride positron emission tomography?

Author

Michelle L Frost; Musib Siddique; Glen M Blake; Amelia EB Moore; Paul J Schleyer; Joel T Dunn; Edward J Somer; Paul K Marsden; Richard Eastell; Ignac Fogelman

Publisher

American Society for Bone and Mineral Research; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0884-0431)

Published

2011

Language

EN

Field

Medicine (Health Sciences)