About this Engineering article
Tumor-targeting peptide functionalized PEG-PLA micelles for efficient drug delivery by Yue Cai; Zhuomin Xu; Qi Shuai; Fangtao Zhu; Jiao Xu; Xin Gao; Xuanrong Sun is a Engineering article available to read on EtoBox.
Because of their excellent capacity to significantly improve the bioavailability and solubility of chemotherapy drugs, block copolymer micelles are widely utilized for chemotherapy drug delivery. In order to further improve the anti-tumor ability and reduce unwanted side effects of drugs, tumor-targeting peptides were used to functionalize the surface of polymer micelles so that the micelles can target tumor tissues. Herein, we synthesized a kind of PEG-PLA that is maleimide-terminated and then conjugated with a specific peptide F3 which revealed specific capacity binding to nucleolin that is overexpressed on the surface of many tumor cells. Then, F3 conjugated, paclitaxel loaded nanoparticles (F3-NP-PTX) were prepared as stable micelles that displayed an enhanced accumulation via a peptide-mediated cellular association in human breast cancer cells (MCF-7). Furthermore, F3-NP-PTX showed a prominent anti-tumor efficacy compared with non-targeting nanoparticles (NP-PTX) both in vitro and in vivo, and showed great potential as an efficacious targeting drug delivery system for breast cancer treatment.
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Yue Cai; Zhuomin Xu; Qi Shuai; Fangtao Zhu; Jiao Xu; Xin Gao; Xuanrong Sun
- Publisher
- The Royal Society of Chemistry; Royal Society of Chemistry; Royal Society of Chemistry (RSC) (ISSN 2047-4830)
- Published
- 2020
- Language
- EN
- Field
- Engineering (Physical Sciences)