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Cancer Immune Therapy Using Engineered ‛Tail-flipping’ Nanoliposomes Targeting Alternatively Activated Macrophages by Praneeth R. Kuninty; Karin Binnemars-Postma; Ahmed Jarray; Kunal P. Pednekar; Marcel A. Heinrich; Helen J. Pijffers; Hetty ten Hoopen; Gert Storm; Peter van Hoogevest; Wouter K. den Otter; Jai Prakash is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Cancer Immune Therapy Using Engineered ‛Tail-flipping’ Nanoliposomes Targeting Alternatively Activated Macrophages about?
## Abstract Alternatively-activated, M2-like tumor-associated macrophages (TAM) strongly contribute to tumor growth, invasiveness and metastasis. Technologies to disable the pro-tumorigenic function of these TAMs are of high interest to immunotherapy research. Here we show that by designing engineered nanoliposomes bio-mimicking peroxidated phospholipids that are recognised and internalised by scavenger receptors, TAMs can be targeted. Incorporation of phospholipids possessing a terminal carboxylate group at the sn-2 position into nanoliposome bilayers drives their uptake by M2 macrophages with high specificity. Molecular dynamics simulation of the lipid bilayer predicts flipping of the sn-2 tail towards the aqueous phase, while molecular docking data indicates interaction of the tail with Scavenger Receptor Class B type 1 (SR-B1). In vivo, the engineered nanoliposomes are distributed specifically to M2-like macrophages and, upon delivery of the STAT6 inhibitor (AS1517499), zoledronic acid or muramyl tripeptide, these cells promote reduction of the premetastatic niche and/or tumor growth. Altogether, we demonstrate the efficiency and versatility of our engineered “tail-flipping” na
Who reads Cancer Immune Therapy Using Engineered ‛Tail-flipping’ Nanoliposomes Targeting Alternatively Activated Macrophages?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Praneeth R. Kuninty; Karin Binnemars-Postma; Ahmed Jarray; Kunal P. Pednekar; Marcel A. Heinrich; Helen J. Pijffers; Hetty ten Hoopen; Gert Storm; Peter van Hoogevest; Wouter K. den Otter; Jai Prakash
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)