About this Biochemistry, Genetics and Molecular Biology article
Mitochondria-targeted antioxidant SkQR1 ameliorates gentamycin-induced renal failure and hearing loss by S. S. Jankauskas; E. Y. Plotnikov; M. A. Morosanova; I. B. Pevzner; L. D. Zorova; V. P. Skulachev; D. B. Zorov is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
The influence of the mitochondria-targeted antioxidant SkQR1 on gentamycin-induced nephrotoxicity and ototoxicity has been analyzed. SkQR1 reduces the death of kidney epithelium cells and decreases the severity of renal failure caused by gentamycin application and also lowers the animals' mortality. Treatment with SkQR1 also decreases gentamycin-induced hearing loss. Mitochondria-targeted antioxidants, such as SkQR1, are new promising agents for preventing negative consequences of therapy with antibiotics.
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- Author
- S. S. Jankauskas; E. Y. Plotnikov; M. A. Morosanova; I. B. Pevzner; L. D. Zorova; V. P. Skulachev; D. B. Zorov
- Publisher
- Pleiades Publishing Ltd
- Published
- 2012
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)