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Influence of Ca2+ and ethanol on the aggregation and thermal phase behaviour of l-dihexadecylphosphatidylcholine liposomes by Anu Kõiv; Paavo K.J. Kinnunen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Influence of Ca2+ and ethanol on the aggregation and thermal phase behaviour of l-dihexadecylphosphatidylcholine liposomes about?
The influence of Ca 2+ and ethanol on vesicle aggregation and thermal phase behaviour of the diether lipid 1,2-dihexadecylphosphatidylcholine (DHPC) was studied by light absorbance and DSC. At temperatures below the pretransition the ethanolinjected vesicles of L-DHPC were rapidly aggregated by Ca 2÷. Upon raising the cation concentration a biphasic increase in aggregation saturating at an approximate [Ca2+]/[lipid] ratio of 1.5:1 was observed. Further increase in [Ca 2÷] up to [Ca2+]/[lipid] stoichiometries exceeding 2.5:1 led to the loss of aggregation. Removal of ethanol by dialysis abolished Ca2+-induced aggregation. Ethanol-injected vesicles of the ester-linked L-dipalmitoylphosphatidylcholine (L-DPPC) or the racemic DL-DHPC were not aggregated by Ca 2+ thus indicating the importance of the absence of ester carbonyls as well as the stereochemical configuration of the lipid in determining the mode of interaction of DHPC with Ca 2+. Differential scanning calorimetry of multilamellar liposomes of L-DHPC showed an increase by 8 ° in the pretransition temperature Tp in the presence of 250 mM ethanol. Both with and without ethanol, increasing concentrations of Ca 2+ corresponding to
Who reads Influence of Ca2+ and ethanol on the aggregation and thermal phase behaviour of l-dihexadecylphosphatidylcholine liposomes?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Anu Kõiv; Paavo K.J. Kinnunen
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-3084)
- Published
- 1992
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)