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Differentiation of Human Induced Pluripotent Stem Cells Into Erythroid Cells by Mohsen Ebrahimi; Mehdi Forouzesh; Setareh Raoufi; Mohammad Ramazii; Farhoodeh Ghaedrahmati; Maryam Farzaneh is a Medicine article available to read on EtoBox.

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## Abstract During the last years, several strategies have been made to obtain mature erythrocytes or red blood cells (RBC) from the bone marrow or umbilical cord blood (UCB). However, UCB-derived hematopoietic stem cells (HSC) are a limited source and in vitro large-scale expansion of RBC from HSC remains problematic. One promising alternative can be human pluripotent stem cells (PSCs) that provide an unlimited source of cells. Human PSCs, including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are self-renewing progenitors that can be differentiated to lineages of ectoderm, mesoderm, and endoderm. Several previous studies have revealed that human ESCs can differentiate into functional oxygen-carrying erythrocytes; however, the ex vivo expansion of human ESC-derived RBC is subjected to ethical concerns. Human iPSCs can be a suitable therapeutic choice for the in vitro/ex vivo manufacture of RBCs. Reprogramming of human somatic cells through the ectopic expression of the transcription factors (OCT4, SOX2, KLF4, c-MYC, LIN28, and NANOG) has provided a new avenue for disease modeling and regenerative medicine. Various techniques have been developed to genera

Who reads Differentiation of Human Induced Pluripotent Stem Cells Into Erythroid Cells?

Author

Mohsen Ebrahimi; Mehdi Forouzesh; Setareh Raoufi; Mohammad Ramazii; Farhoodeh Ghaedrahmati; Maryam Farzaneh

Publisher

Springer Science and Business Media LLC

Published

2020

Language

EN

Field

Medicine (Health Sciences)