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Diagnostic and prognostic value of EEG in prodromal dementia with Lewy bodies by Jessica Joanne van der Zande; Alida A. Gouw; Inger van Steenoven; Marleen van de Beek; Philip Scheltens; Cornelis Jan Stam; Afina Willemina Lemstra is a Medicine article available to read on EtoBox.

What is Diagnostic and prognostic value of EEG in prodromal dementia with Lewy bodies about?

## Objective Early biomarkers for dementia with Lewy bodies (DLB) are lacking. To determine whether EEG differentiates the prodromal phase of DLB from other causes of mild cognitive impairment (MCI) and whether EEG is predictive for time to conversion from MCI to DLB, we compared EEGs and clinical follow-up of patients with MCI due to DLB with those of patients with MCI due to Alzheimer disease (MCI-AD). ## Methods We compared 37 patients with MCI who developed DLB during follow-up or had an abnormal ^123^I-PF-CIT SPECT scan (MCI-DLB) with 67 age-matched patients with MCI-AD. EEGs were assessed visually with a score of increasing abnormality (range 1–5). We performed fast Fourier transform to analyze the power spectrum. With survival analyses, EEG characteristics were related to time to progression to dementia. ## Results The visual EEG score was higher in MCI-DLB (score >2 in 60%) compared to MCI-AD (score >2 in 8%, p < 0.001). We found frontal intermittent delta activity in 22% of MCI-DLB, not in MCI-AD. Patients with MCI-DLB had a lower peak frequency (7.5 [6.0–9.9] Hz vs 8.8 [6.8–10.2] in MCI-AD, p < 0.001) and more slow-wave activity. Several individual EEG measures showed goo

Who reads Diagnostic and prognostic value of EEG in prodromal dementia with Lewy bodies?

Author

Jessica Joanne van der Zande; Alida A. Gouw; Inger van Steenoven; Marleen van de Beek; Philip Scheltens; Cornelis Jan Stam; Afina Willemina Lemstra

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2020

Language

EN

Field

Medicine (Health Sciences)