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Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans by Kristel Brys; Natascha Castelein; Filip Matthijssens; Jacques R Vanfleteren; Bart P Braeckman is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans about?
## Abstract ## Background The gene __daf-2__ encodes the single insulin/insulin growth factor-1-like receptor of __Caenorhabditis elegans__. The reduction-of-function allele __e1370__ induces several metabolic alterations and doubles lifespan. ## Results We found that the __e1370__ mutation alters aerobic energy production substantially. In wild-type worms the abundance of key mitochondrial proteins declines with age, accompanied by a dramatic decrease in energy production, although the mitochondrial mass, inferred from the mitochondrial DNA copy number, remains unaltered. In contrast, the age-dependent decrease of both key mitochondrial proteins and bioenergetic competence is considerably attenuated in __daf-2(e1370)__ adult animals. The increase in __daf-2(e1370)__ mitochondrial competence is associated with a higher membrane potential and increased reactive oxygen species production, but with little damage to mitochondrial protein or DNA. Together these results point to a higher energetic efficiency of __daf-2(e1370)__ animals. ## Conclusions We conclude that low __daf-2__ function alters the overall rate of ageing by a yet unidentified mechanism with an indirect protective effe
Who reads Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Kristel Brys; Natascha Castelein; Filip Matthijssens; Jacques R Vanfleteren; Bart P Braeckman
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, c2003-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc.; Research Square (ISSN 1741-7007)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)