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A Mathematical Model for Yeast Respiro-fermentative Physiology by Hanegraaf, P. P. F.; Stouthamer, A. H.; Kooijman, S. A. L. M. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is A Mathematical Model for Yeast Respiro-fermentative Physiology about?

A mechanistic model is presented that describes the respiro-fermentative physiology of yeast. The model assumes the presence of multiple types of glucose carriers and multiple assimilation pathways. Respiro-fermentative physiology is explained by the mechanistic response of the different types of carriers and assimilation pathways on the substrate concentration. At low substrate concentrations, glucose is taken up mainly via a high af®nity carrier with a low maximum uptake rate. At high substrate concentrations, this carrier becomes saturated and the main pathway for glucose uptake is via a low af®nity carrier with a high maximum uptake rate. The price to pay for the high uptake rate is a lowered assimilation ef®ciency, resulting in a low biomass yield. Product formation occurs via the pathway with the high uptake rate. The model explains the link between substrate concentration and product formation generally observed in the literature on yeast and bacteria. Model parameter values are estimated by ®tting data from the literature. The model distinguishes itself from other models in that it does not rely on the presence of switches, such as the `critical dilution rate', or on the as

Who reads A Mathematical Model for Yeast Respiro-fermentative Physiology?

Author

Hanegraaf, P. P. F.; Stouthamer, A. H.; Kooijman, S. A. L. M.

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); John Wiley & Sons Inc.; [Chichester]; [New York]: John Wiley & Sons, ©1985-; Wiley; Hindawi Limited (ISSN 0749-503X)

Published

2000

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)