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Paradigm Shift: Functional Dyspepsia—A “Leaky Gut” Disorder? by Jan Tack; Jolien Schol; Karen Van den Houte; I-Hsuan Huang; Florencia Carbone is a Medicine article available to read on EtoBox.

What is Paradigm Shift: Functional Dyspepsia—A “Leaky Gut” Disorder? about?

## Abstract For up to 2 decades, pathophysiological research in functional dyspepsia focused on gastric sensorimotor dysfunction underlying symptom generation. Recent pathophysiological research has focused on low-grade inflammation in the duodenal mucosa. Emerging evidence confirms a loss of mucosal integrity in the duodenum in functional dyspepsia, and this is confirmed in a confocal laser endomicroscopy study demonstrating altered mucosal barrier function and pyroptosis. This technique may help to establish underlying mechanisms and evaluate novel therapeutic approaches to functional dyspepsia.

Who reads Paradigm Shift: Functional Dyspepsia—A “Leaky Gut” Disorder??

Author

Jan Tack; Jolien Schol; Karen Van den Houte; I-Hsuan Huang; Florencia Carbone

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2020

Language

EN

Field

Medicine (Health Sciences)