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Can I read Association of Age and Inflammatory Disease Activity in the Pivotal Natalizumab Clinical Trials in Relapsing-remitting Multiple Sclerosis on EtoBox?
Association of Age and Inflammatory Disease Activity in the Pivotal Natalizumab Clinical Trials in Relapsing-remitting Multiple Sclerosis by Eva M Strijbis; Eline Coerver; Jop Mostert; Zoé L E van Kempen; Joep Killestein; Jacynthe Comtois; Pavle Repovic; James D Bowen; Gary Cutter; Marcus Koch is a Medicine article available to read on EtoBox.
What is Association of Age and Inflammatory Disease Activity in the Pivotal Natalizumab Clinical Trials in Relapsing-remitting Multiple Sclerosis about?
Background Focal inflammatory disease activity in relapsing-remitting multiple sclerosis (RRMS) diminishes with increasing age. Here we use patient-level data from randomised controlled trials (RCTs) of natalizumab treatment in RRMS to investigate the association of age and inflammatory disease activity. Methods We used patient-level data from the AFFIRM (natalizumab vs placebo in relapsing-remitting MS,NCT00027300) and SENTINEL (natalizumab plus interferon beta vs interferon beta in relapsing remitting MS,NCT00030966) RCTs. We determined the proportion of participants developing new T2 lesions, contrast-enhancing lesions (CELs) and relapses over 2 years of follow-up as a function of age, and investigated the association of age with time to first relapse using time-to-event analyses. Results At baseline, there were no differences between age groups in T2 lesion volume and number of relapses in the year before inclusion. In SENTINEL, older participants had a significantly lower number of CELs. During both trials, the number of new CELs and the proportion of participants developing new CELs were significantly lower in older age groups. The number of new T2 lesions and the proportion
Who reads Association of Age and Inflammatory Disease Activity in the Pivotal Natalizumab Clinical Trials in Relapsing-remitting Multiple Sclerosis?
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- Author
- Eva M Strijbis; Eline Coerver; Jop Mostert; Zoé L E van Kempen; Joep Killestein; Jacynthe Comtois; Pavle Repovic; James D Bowen; Gary Cutter; Marcus Koch
- Publisher
- BMJ
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)