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Expression of the homeodomain transcription factor Meis2 in the embryonic and postnatal retina by Keely M. Bumsted‐O'Brien; Anita Hendrickson; Silke Haverkamp; Ruth Ashery‐Padan; Dorothea Schulte is a Neuroscience article available to read on EtoBox.
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## Abstract Members of the Meis subfamily of homeodomain‐containing transcription factors play important roles during development and disease. Here we report that the Meis family protein Meis2 is expressed by a subpopulation of γ‐aminobutyric acid (GABA)ergic amacrine (AM) cells in the adult and embryonic retina of different vertebrate species. In mice, Meis2‐expressing (Meis2+) AM cells are not cholinergic or dopaminergic, but some are immunoreactive for neuronal nitric oxide synthase (bNOS). About 50% of the mouse Meis2+ AM cell population expresses the calcium‐binding protein calretinin, and some Meis2+ AM cells show characteristics of Type II CD‐15+ cells. AM cell expression of Meis2 is lost in a conditional knockout mouse model for Pax6, indicating a dependency upon Pax6. Bromodeoxyuridine pulse labeling experiments and immunohistochemical staining for the neuronal marker NeuN in embryonic mouse retinae indicate that Meis2 is an early marker for newly postmitotic AM cells. In addition, taking advantage of the protracted retinal development in humans, we show that newly generated AM cells express Meis2 before adopting the GABAergic or glycinergic neurotransmitter phenotype. As
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- Author
- Keely M. Bumsted‐O'Brien; Anita Hendrickson; Silke Haverkamp; Ruth Ashery‐Padan; Dorothea Schulte
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)
- Published
- 2007
- Language
- EN
- Field
- Neuroscience (Life Sciences)