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Increasing Cancer in Adolescents and Young Adults: Cancer Types and Causation Implications by Archie Bleyer is a Medicine article available to read on EtoBox.

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This study aimed to identify cancer incidence trends in the United States and globally in adolescents and young adults (AYAs) 15-39 years of age, by sex, and to speculate on causes for trend changes. Methods: For the United States, SEER\*Stat was used to obtain average annual percent change (AAPC) trends in cancer incidence during the period 2000-2019 among 395,163 AYAs. For global data, the source was the Institute of Health Metrics and Evaluation and its sociodemographic index (SDI) classification system. Results: In the United States, the invasive cancer incidence increased during the period 2000-2019 in both females (AAPC: 1.05, 95% CI: 0.90-1.20, p << 0.001) and males (AAPC: 0.56, 95% CI: 0.43-0.69, p << 0.001). A total of 25 and 20 types of cancers increased statistically significantly in female and male AYAs, respectively. Among potential causes for the increases, the obesity epidemic in the United States strongly correlates with the overall cancer increase in both its female (Pearson correlation coefficient R 2 = 0.88, p = 0.0007) and male (R 2 = 0.83, p = 0.003) AYAs, as does the most common malignancy in American AYAs, breast cancer (R 2 = 0.83, p = 0.003). Worldwide, can

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Author

Archie Bleyer

Publisher

Mary Ann Liebert Inc

Published

2023

Language

EN

Field

Medicine (Health Sciences)