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Can I read The Availability of Iron Is Involved in the Murine Experimental Toxoplasma gondii Infection Outcome on EtoBox?
The Availability of Iron Is Involved in the Murine Experimental Toxoplasma gondii Infection Outcome by Oliveira, Mário Cézar; Coutinho, Loyane Bertagnolli; Almeida, Marcos Paulo Oliveira; Briceño, Marisol Pallete; Araujo, Ester Cristina Borges; Silva, Neide Maria is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The Availability of Iron Is Involved in the Murine Experimental Toxoplasma gondii Infection Outcome about?
Iron is an important constituent of our environment, being necessary for both mammalian and pathogenic protozoa survival. Iron-containing proteins exert a wide range of biological processes such as biodegradation and biosynthesis, as well as immune function, fetal development, and physical and mental well-being. This work aimed to investigate the effect of iron deprivation in __Toxoplasma gondii__ infection outcome. C57BL/6 mice were orally infected with __T. gondii__ and treated with an iron chelator, deferoxamine, or supplemented with iron (ferrous sulfate), and the parasitism as well as immunological and histological parameters were analyzed. It was observed that the infection increased iron accumulation in the organs, as well as systemically, and deferoxamine treatment diminished the iron content in serum samples and intestine. The deferoxamine treatment decreased the parasitism and inflammatory alterations in the small intestine and lung. Additionally, they partially preserved the Paneth cells and decreased the intestinal dysbiosis. The ferrous sulfate supplementation, despite not significantly increasing the parasite load in the organs, increased the inflammatory alterations
Who reads The Availability of Iron Is Involved in the Murine Experimental Toxoplasma gondii Infection Outcome?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Oliveira, Mário Cézar; Coutinho, Loyane Bertagnolli; Almeida, Marcos Paulo Oliveira; Briceño, Marisol Pallete; Araujo, Ester Cristina Borges; Silva, Neide Maria
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI) (ISSN 2076-2607)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)