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Oxidative Stress-Induced ZEB1 Acetylation Drives A by artem.samarin99 is a document available to read on EtoBox.
This study identifies the role of oxidative stress-induced ZEB1 acetylation in promoting a hybrid epithelial-mesenchymal phenotype and lung metastasis in triple-negative breast cancer (TNBC). The research highlights a CBP/SIRT1 axis that regulates ZEB1 acetylation, enhancing tumor cell plasticity and resistance to oxidative damage, thereby facilitating metastasis. Targeting this acetylation mechanism may offer a novel therapeutic strategy against metastatic TNBC.
- Author
- artem.samarin99
- Language
- EN